astrazeneca vaccine ingredients pdf

It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). 0000106271 00000 n For countries that have not yet achieved high vaccine coverage rates in the high-priority groups and that are experiencing high incidence of COVID-19 cases combined with vaccine supply constraints, longer intervals i.e. Oxford-AstraZeneca COVID-19 vaccine efficacy. 0000007190 00000 n %PDF-1.7 % The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. 0 <>stream 0000098877 00000 n Function. Unit dose strength (s) > 0.7 1011 vp/mL. Dont include personal or financial information like your National Insurance number or credit card details. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. hb```b``9 |Abl,=@00M(P~. Solution for injection. By reporting side effects you can help provide more information on the safety of this vaccine. Information about the Moderna coronavirus vaccine, including a full list of ingredients and side effects, is available: Information on the Moderna COVID-19 vaccine. If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. 0000014217 00000 n If you miss a scheduled injection, you may not be fully protected against COVID-19. hb``g``oc`c` @1v=k}u F'SUNZ You can help by reporting any side effects you may get. The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. hb```(1A;B% health workers and immunocompromised persons should be prioritised. A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. ____________________________________________________________________________________. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. You will be told when you need to return for your second injection of COVID-19 Vaccine AstraZeneca. How COVID-19 Vaccine AstraZeneca is given 4. Health information in your inbox, every other week. Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. Most people have been exposed to them in their lives. 0000004537 00000 n Success! 55 0 obj Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. endstream endobj startxref If you are not sure, talk to your doctor, pharmacist or nurse. 0000003743 00000 n Vaccine ingredients; Nucleic acid and viral vector vaccines explained . s/s's?3on1;XX(@?<=f@(tv4;r% ~IX 0000093171 00000 n 0000003465 00000 n Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. Like any vaccine, the COVID-19 vaccines do come with potential side effects. impact. 581 0 obj <>stream As of May 2022, people over age 5 are eligible to receive an FDA-approved COVID-19 vaccine.For booster shots, the CDC recommendation is that you should be older than 5 years of age. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. <>/Metadata 30 0 R>> 0000010323 00000 n 0000004065 00000 n endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. One dose (0.5 ml) contains: endstream endobj 75 0 obj <> stream Keep this medicine out of the sight and reach of children. For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. 0000102287 00000 n endstream endobj startxref /Info 87 0 R Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. But individuals may choose to delay vaccination for 3 months following the infection. The majority of these cases occurred within the first four weeks following vaccination. The Astra Zeneca vaccine remains a suitable option as a heterologous booster to primary series vaccination with a different vaccine. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. 0000102371 00000 n xcbd```b``A$c0{.fH "uAY@1bFg210MW it contains the weakened adenovirus encoding the SARS CoV 2 Spike glycoprotein, as well as the following excipients: L-histidine L-histidine hydrochloride monohydrate magnesium chloride hexahydrate. information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women. 0000055209 00000 n Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. It's only capable of delivering the DNA," he said. If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. A court in Belgium . COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). WHO does not recommend pregnancy testing prior to vaccination. endobj The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. >!V9j5LYHCz. ;BV 0000093244 00000 n 0000003890 00000 n Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. Vaccine AstraZeneca and those who received control. It will take only 2 minutes to fill in. Some cases had a fatal outcome. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> Once approved, the drugmaker will work with national governments and international health organizations to monitor vaccine recipients for potential side effects from the vaccine that were not seen in clinical trials (this is called surveillance). Well send you a link to a feedback form. Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC. A very rare adverse event called Thrombosis with Thrombocytopenia Syndrome (TTS), involving unusual and severe blood clotting events associated with low platelet counts, has been reported after vaccination with this vaccine. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. Oops! ]0[ COVID-19 Vaccine AstraZeneca contains genetically modified organisms (GMOs). This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection On his way to a meeting to present . See the end of section 4 for how to report side effects. 0000006540 00000 n 0000104953 00000 n these events. Andrew Pollard was in a French taxi when he realised what was coming. 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. 6. . Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. 0000000016 00000 n Possible side effects 5. trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream 18 June 2021. Moderna bivalent COVID-19 vaccine. Some excipients are added to a vaccine for a specific purpose. 0000024916 00000 n dose regimen of this vaccine is believed to be more protective against variants of concern than a single dose alone. SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. %%EOF 0000097788 00000 n COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. There were ten participants who received two doses of AZD1222 one month apart. 56 0 obj United Kingdom, MedImmune Pharma B.V., Nijmegen 0000098956 00000 n This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. How to store COVID-19 Vaccine AstraZeneca 6. It should be noted that the full two There 0000009792 00000 n AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. 53 0 obj Component. Store in a refrigerator (2C to 8C). Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). That way, when a person is exposed to COVID-19, its immune system will recognize the part of the virus that has those spike proteins and will know how to how to fight it. Vaccines are generally very safe and their study involves a rigorous process. hbbd```b``3@$1dYL`)`5w. request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. 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