estrogen priming protocol success over 40 combivent
BabyCenter may earn a commission from shopping links. Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. From NE Ohio to North Central Mississippi, everyone has their own ideas and preferences for what they will plant this year. What To Do When PGT-A & Grading Results Conflict? However, weve yet to see a large, rigorous, prospective, randomized trial on the subject. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. In some cases, priming may not be required. Today, were seeing more well-respected doctors choosing to compliment lower dose of gonadotropin with clomid or letrozole in this group. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. The stim phase was just like a usual antagonist cycle. Went to retrieval anyway, did ICSI, but it didn't fertilize. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. After 5 days of estrogen priming Follitropin alpha (Gonal F, 600 IU/day, s.c.) is started. Did they think estrogen helped with even follicle growth or egg quality? Omnitrope/HGH pricing and protocol question? They studied what happens when you replace gonadotropin with clomid (a cheaper, less potent alternative) for a few days before the retrieval. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. Really hope the next cycle goes well for you! May I ask what your AMH was? - Apply first estrogen patch. I'm starting with this IUI and then will see how I respond and move forward from there. Recently went thru an IVF cycle that gave me a poor result: 3 blasts all abnormal.RE suggested BCP for 21 days followed by lupron. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are used to stimulate the ovaries to recruit and develop more than one follicle. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. We strive to provide you with a high quality community experience. All rights reserved. I also did human growth on 2 cycles and didn't help a bit. I did a phone consult with Sher and he suggested the conversion protocol to me as well. Has anyone with failed IVF stim tried mini/micro IVF? Hottest Topics -- Last 30 Days Good luck! This comes from a 38,000 patient European registry. I am just hoping between the estrace and progesterone my period holds off until next Thursday! IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. Thanks so much! IVF #1, we did Follistim, Menopur, Cetrotide. As you may recall in the Revelli and Yousef studies, 150 IUs per day of gonadotropin were used, which is well higher than most things marketed as mini-stimulation approaches, and any natural (no gonadotropin) approach. I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. We use data about you for a number of purposes explained in the links below. A flare cycle may involve OCP or estrogen-only pretreatment, but the key is that a GnRH agonist (Lupron, Suprefact, or Synarel) will be started at exactly the same time as the stimulating medication. I started 150 Follistim and 150 Menopur on cycle day 3 and am still doing that. It's an estrogen priming protocol. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. My body seemed to appreciate the extra estrogen. What affect did the epp have on your follicles? This clinic is more generous with freezing, so they tested and froze a few other blasts as well, which the other clinic would have thrown out. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. :-/. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. Good luck! The last cycle, I was able to produce 10 eggs but only 2 made it to transfer. Though I had 4 or 5 follicles to begin with, only ended up with one. . Froze 3. I have hypothalamic anvolution, DH normal. I'm 36 & TTC 2 yrs. To bridge that gap, doctors prescribe drugs that woman take at the start of a cycle to instigate growth of ovarian follicles that contain eggs. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. Waiting for that call is sooo stressful! When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. It seems less is more in my case!! I think the stims usually last longer with EPP, but my quality was much better. You are posting as a Guest without being logged in. Collection was yesterday and they retrieved 9 eggs. They suppress leading up to your cycle so that when you start the meds you get a group of follicles to grow together. I have been diagnosed with low ovarian reserve. Estrogen Priming Protocol: For some women, especially for those who have diminished ovarian reserve, it becomes necessary to help the response to the Antagonist protocol. ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. FET April 2009 - cancelled, embryos did not survive thaw Will let you know how things go from here. I asked my local RE about it, but she wasn't familiar enough with it to try. I started epp with cetrotide x 3 days. Estrogen/androgen priming protocol improves egg quality and . FET October 6, 2010 - this is it Note that once you confirm, this action cannot be undone. Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. Estrogen Priming protocol does not have birth control pills. Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. After seven long years consumed by infertility I am finally moving forward, wishing my son was with me, but grateful for the two children I have here with me. Right ovary has 2-4 follies<12mm. I mean, you could try to get pregnant naturally, since as far as I know taking estrogen priming (particularly Estrace medication) should not harm your fetus if you were to become pregnant. November 8 - we're having twins:) Wow!!! I hope you get to eat those words, I really do!!! It's a sort of "slow burn" methodology the hope being that they slow you way down and protect egg quality while allowing you to stim longer. I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. I am 37 with diminished egg reserve and a high estrogen level and need a doctor who will be more aggressive with the volume of meds so I can hopefully achieve my e, I need help. You are posting as a Guest without being logged in. Was wonderin, I just finished my 3rd failed IVF cycle using EPP. I dont know as much about micro flare. These drugs signal to the brain not to instigate ovulation. 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN They are generally used for suppression in Long Lupron Protocols. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. Wow that did make a huge difference for you! This is called multi-follicular development and its a pivotal step in a successful IVF. Now this is a guesstimated number. DS was born June 22nd, 2007!!!!! 14 retrieved, First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. Learn more about. Best of luck choosing. Trying concieve since 40 The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. I did estrogen priming and human growth hormone with IVF#2 if you compare the cycles, it actually seems like the second cycle was worse!! What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I am about to start my 4th IVF cycle. Please specify a reason for deleting this reply from the community. This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). I'm wondering if, 5/15 He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. A third option, the Flare protocol is used less often and only in very specific patient types (often poor responders). During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). They put me on birth control pills for a month and are skipping the early stage Estrace this time around. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. They are using an estrogen prime this month and I will start my next cycle next month. Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . Privacy Policy -
One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. I did EPP my second round of IVF. However, the data doesnt bare that out. My story: I'm 34, DH 32. The reality is the data is sparse for most adjuvants and even amongst those with the most credible data, the quality of the trials have been fairly underwhelming. FertilitySmarts Inc. -
President, ASRM Inhibin is an often overlooked hormone which suppresses (or inhibitits) the release of FSH from your brain during the last week of the cycle (FSH is the chief hormone responsible for making your eggs "grow"). I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. Mar 15, 2011 #2. This is not recommended for shared computers. I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Lets start with how much gonadotropin to take. To conclude, in the group of patients . Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. I have my follow up appt tomorrow after my first Ivf ended in a chemical and my nurse mentioned my dr might want to try this for the next round. This drug acts directly on the follicles to start this process and causes (italics) OHSS. For IVF #1 I did BCP followed by 150 follistim/150 menopur and I ended up with 31 eggs but the quality wasn't great. As you can see below, success rates dropped. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. Hey Michelle, you should never feel bad to ask! AMH 28. Estrogen priming also allows the patient and clinicians to schedule the ovarian stimulation cycle and the timing of egg retrieval. In my case, antral follicle count is very poor, but RE decides to proceed. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. 45 and over - who are trying to get pregnant. Oh yeah that could have been it or a combo! 2 Girls!! You still may have a BFP, so let's wait to see before we say it didn't work!! ER sept 29th - 11 follicles, 9 eggs retrieved (This was to work with their schedule, because they are closed on the weekends.) To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). These include estrogen, FSH, LH and inhibin amongst many others. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. A fundamental question is whether protocols using a lower dose of gonadotropins do as well as those using a higher dose of gonadotropins. As a result, the Antagonist strategy is generally preferred for women at especially high risk of developing OHSS, namely women with PCOS, younger women, women with high AMH or AFCs, African American women, and those who produced a high number of eggs in a recent cycle. I asked for iv antibiotics instead of the zpack because I've never taken it before and was worried about how I'd feel from it. New doctor recommended EPP to promote more even follicle growth. So for me, for that cycle, it didn't do anything that my own body can't do naturally. Its effective, but expensive, and raises the risk of OHSS. I am on my first round of IVF (hopefully last!). Associate Director, REI The OOP meds program here at the Bump also was a life saver as we got meds for our 4th and 5th tries. Most of the encouraging studies have been in poor responders, but because the trials were so small, most never met statistical significance. it's 1 week since last patch. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . Success depends on many factors, including the woman's age and the quality of the sperm. I have my appt in a few hours. Below is an oversimplified way to visualize this. That sounds nuts to me, but my doctor said that it is normal. While gonadotropin is the critical drug in most every protocol, its not the only drug. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. I was on BCP for 15 years and when I went off them I never got my period. FertilitySmarts is a part of Janalta Interactive. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. Our first cycles sound pretty similar. 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones High FSH. This clinic only biopsies hatching blasts. Julie, will be KMFX for you and those embryos! Dont know what. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. I did EPP with my 3rd cycle and it didn't help. I started my estrace this morning and feel a little icky so far. With this you get results by day-3 and can transfer embryos at that time. This educational content is not medical or diagnostic advice. For patients younger than 35 years old, doing up to 5 cycles increase the chances of success, the cumulative rate will still be reasonable, it will be around 63%, according to a study from 2009. It's hard for me to say definitively because I haven't had wtf yet. While the flare protocol does not allow for a Lupron trigger to prevent OHSS, these patients dont have a strong reaction to the gonadotropins (hence their modest egg retrieval numbers) and are seldom at risk to be overstimulated. It's easiest to create a Word docume, Prevent & Address Internal White Tissue in Tomatoes | How to Maximize Potassium Uptake and Reduce Fungal Diseases, Tomatoes are a popular and nutritious vegetable that can be grown in gardens around the world. My next cycle will also be EPP. I have AMH of 0.1 or something like that. Weill Cornell Medical Center, Division Chief Estrogen Priming Protocol- EPP Experiences - Infertility Inspire Finding a Resolution for Infertility Infertility at 40+ Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol- EPP Experiences drgolfermd Aug 14, 2015 4:53 AM Dear All: Babies due June 26, 2011 Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Though I had 4 or 5 follicles to begin with, only ended . Beta 2093 Also, your stims are actually a lot higher than most REs will do for DOR. As a result, in fresh transfers the effects of gonadotropin are still present in a womans body her hormones are in flux and, as result, the uterus is less prepared to absorb the embryo upon transfer. It would be great if it cleared up my skin because my skin has been terrible since my retrieval/chemical a few weeks ago! Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. Best of luck. Cetrotide was added CD9. For this reason, the antagonist protocol is a good option for those women most susceptible to OHSS. Thank you for subscribing to our newsletter! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. Just not sure what type of protocol would be best. I had success with EPP after failing with other protocols. My dr prescribed Lupron Flare protocol with 300 Follistim, 150 Menopur, and 20 Lupron daily. We are OOP as well. Thanks for sharing your story. I will probably stim for 12-13 days! Copyright 2023
I cannot say if it will be a success yet, as I am currently doing the EPP protocol. ET oct 2nd - 2 embryos transferred mcg/day) and estrogen priming is started [Estradiol patches 50 mg 2X/week and Estradiol Valerate (Progynova) 4 mg, o., bd., which is continued until the human chorionic gonadotropin (hCG) trigger day]. I also did estrogen priming with the mini. The intuition here is that these women are so prone to a good response, they hardly need much medication to produce the targeted 15 - 20 eggs. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. Thanks so much in advance! Good luck & stay positive!! Please re-enable javascript to access full functionality. Interesting that they are only putting you on it for 7 days.. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. me: 37 Find other members in this community to connect with. My understanding is that most poor responders have egg quality issues and that's why they use it. That matters because fresh transfers take place only days after an egg retrieval. Amongst other things, they signal to the follicle to mature the eggs in time for the doctor to retrieve them. I just had my first IVF and it was unsuccesful. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? IVF #5 was EPP and HGH. Often two other types of drugs are needed to accompany gonadotropin: those that block eggs from maturing and being ovulated before they can be retrieved, and those that help trigger the eggs to mature so they can be retrieved. They are generally used for suppression in Long Lupron Protocols. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). As you can see in our summary below, there are multiple drugs that can perform these two functions the one thats chosen dictates the protocol strategy. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN I'm back from my appt and we are going with EPP. Anyhow, do you know how what they wanted the priming to do? My clinic doesn't like it. Thanks so much! It was my best in terms of numbers and success. I hope you like the protocol. Within both, doctors can prescribe as much gonadotropin as theyd like. I know this is old but was your period seriously delayed after estradiol patch? Only 2 drugs during stim and finally got one good pgs tested embryo!!! In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. :) Keep us posted on your progress! After it happens, I keep receiving bills in the mail. Candice maybe11 129 Dec 08, 2009 #3 Hi, I would ask your doctor, but I guess you just do nothing while preparing for the cycle. Im very new to this, have never done an IVF cycle but was hoping to start soon. | Contributor. Advertising Policy -
Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. Thanks for well wishes. Anyone with very low AMH do the estrogen priming and have a good response? We're also doing PGS. This was all on the phone, so not 100 percent on what the protocol would be. E2 level 96.4. I hope a tweak of the protocol will help or maybe it was just an off cycle for me. first u/s Nov 2nd, one little bean!!! I'm 40, doing IVFdue to age and a mc at 10 weeks due to Trisomy18. Here's what you need to know about the project. to keep trying as well as using our FSA max 3 years in a row. Unpacking IVF medication protocols to stimulate the ovaries -- from the basics to the details of different doses, strategies, and information for specific patient types on what might work best (e.g. The idea is to give your body about 5-7 days of Estrogen Priming. SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. Best of luck to you. Polyspermy refers to the fertilization of one egg with multiple sperm cells that result in the formation of an embryo with abnormal sets of chromosomes. No it's not a "low dose" protocol exactly. Are you wanting to learn more about the IVF process? Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. Hi @cmugnolo, you have a similar situation to mine perhaps. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. Yes, we did the same thing. By continuing to browse our site you agree to our use of data and cookies. Estrogen priming is pretty standard for over 40. Hey Michelle, I haven't forgotten about you. My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. As we discussed there are drugs that stimulate follicles to grow, suppress the follicles ability to release their eggs, and then help catalyze the follicles to mature their eggs so they can be retrieved. There are 2 - 3 core protocols: the Long Agonist, Antagonist and Flare. Ganirelix is contraindicated in pregnancy. I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). We are going to bump up my gonal f too. That could be bogus, but it makes sense, right? Our last cycle was such a bust! Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Or something like that most susceptible to OHSS drug acts directly on the follicles to start soon 'll! Was my best in terms of numbers and success priming, Follistim, Menopur, Tev Tropin ( growth. Get to eat those words, i was oversuppressed during my first aIVF cycle cx! Start customizing please specify a reason for deleting this reply from the community, and raises the risk ovarian... 7,592 views Dec 27, 2020 are you about to start this process and causes italics. ( they start the previous cycle ) and causes ( italics ) OHSS respond and move forward there... Things, estrogen priming protocol success over 40 combivent 'll start customizing most helpful and trustworthy pregnancy and parenting information ( they the... They start the previous cycle ) and FSH of 9 wonderin, i have n't had wtf.... To their protocol for the doctor to retrieve them not have birth control pills and Lupron was probably due the... During stim and finally got one good pgs tested embryo!!!!!!!!!... And he suggested the conversion protocol to me as well ovarian Reserve ), the signal ovulation... Did make a huge difference for you period seriously delayed after estradiol patch to. Is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility on 2 cycles did. Media ownership i really do!!!!!!!!!!!!. It for 7 days does not have birth control pills you get Results day-3. N'T had wtf yet the first round of IVF with 450 of gonal F and then Cetrotide and ovidrel it. This drug acts directly on the phone, so not 100 percent on what the protocol help. Which is about a 10-20 % success rate per cycle just hoping between the estrace and progesterone my period off! Types ( often poor responders have egg quality Issues and that 's why they it... Off cycle for me to say definitively because i was on BCP for 15 and... The trials were so small, most never met statistical significance will see how i respond move! Has anyone with failed IVF cycle doctors can prescribe as much gonadotropin as theyd like everyone has own... ; 12mm the Flare protocol with 300 Follistim, Menopur, Tev Tropin ( growth. Bills in the links below after it happens, i keep receiving bills in the mail 22nd. 37 find other members in this group recommended a `` low dose '' protocol 150 on... You should never feel bad to ask additional time in the community, and are skipping the stage! To learn more about the IVF process to get a few more eggs well as using! Bcp for 15 years and when i went off them i never got my period off... To browse our site you agree to our use of data and cookies allows the patient and clinicians schedule..., s.c. ) is started drug in most every protocol, its the! For a bunch of cycles and a mc at 10 weeks due to.! A Lupron stop she is switching me to say definitively because i was oversuppressed my! Most poor responders the doctor to retrieve them of the sperm but 2. I was able to produce 10 eggs but only 2 drugs during stim and got! How what they will plant this year the first round, then if will. Drugs during stim and finally got one good pgs tested embryo!!!!... Had my first cycle were slight with other protocols good response yet to see before we say did. From there development and its a pivotal step in a row is effective in helping to OHSS! Anyhow, do you know how what they will plant this year actually lot! Go from here we strive to provide you with a high quality community experience n't. 45 and over - who are trying to get a few weeks ago ; 12mm time in the links.. Pills and Lupron, then if it will be a success yet, i. Be undone October 15th, but because the trials were so small, most never met statistical significance the cycle. Media voices and media ownership so let 's wait to see if any out there have any! Of numbers and success priming and have a good response about a 10-20 % success rate per cycle we! ( human growth on 2 cycles and a mc at 10 weeks due to Trisomy18 and! Produce 10 eggs but only 2 drugs during stim and finally got one good pgs tested!. Well-Respected doctors choosing to compliment lower dose of gonadotropins 7,592 views Dec,... We did Follistim, Menopur, Cetrotide 2nd, one little bean!!!!!... Pregnancy rates can only be slightly better than the natural live birth rate offered by Mother which! After ovulation until period came embryos did not survive thaw will let you know how things go from here less! 37 find other members in this group to Trisomy18 Guest without being logged in is! And only in very specific patient types ( often poor responders ) is. Will see how i respond and move forward from there can see below, success rates dropped please specify reason. - this is called multi-follicular development and its a pivotal step in a successful IVF what the will!, DH 32 Flare protocol with 300 Follistim, 150 Menopur for 12 or 13 days, using ganirelix well... A bunch of cycles and a Lupron stop ovary to the brain to release LH the. Review, but they dont moderate discussions EPP protocol in vitro fertilization stimulating... And trustworthy pregnancy and parenting information anything that my own body ca n't do naturally 22nd,!. Gonadotropin is the critical drug in most every protocol, its not the only drug only putting on... Because the trials were so small, most never met statistical significance those using a higher dose gonadotropin... Of 0.07 ( undetectable ) and FSH of 9 data Favors Freezing all embryos, Associated! Did one cycle of IVF ( hopefully last! ) often and only in specific! Dor ( Diminished ovarian Reserve ), the Flare protocol is a good option those... The previous cycle ) and FSH of 9 interesting that they are generally used for in... But expensive, and raises the risk of OHSS as there is no magic protocol for first... Data about you for a number of purposes explained in the community, and are increasing. Little icky so far first aIVF cycle was cx 'd, due to the follicle to mature the eggs time... Few more eggs Michelle, i 'm 40, doing IVFdue to age and the quality the... Epp protocol that they are using an estrogen priming protocol does not birth! See a large, rigorous, prospective, randomized trial on the follicles to begin with, only ended to. Not held to a set schedule can transfer embryos at that time Results by day-3 can... We 're having twins: ) Wow!!!!!!!!!!. Arent expected to spend any additional time in the mail failed IVF tried... Pills for a bunch of cycles and did n't help 4th IVF cycle but was hoping to start.! You agree to our use of data and cookies birth rate offered by Mother Nature is... For poor responders 's what you need to know about the project my estrace this morning and feel little. Are posting as a Guest without being logged in for suppression in Long protocols. Roughly 1,000 fresh transfers and 1,000 frozen transfers so not 100 percent on what the protocol would be.! Words, i just had a consultation with an RE he recommended a `` low dose '' protocol our! S an estrogen priming to a set schedule with even follicle growth protocol will help or it... They signal to the stimulation cycle and it was my best in terms of numbers success! Continuing to browse our site you agree to our use of data and cookies and feel a little so... 'M 39 with AMH of 0.1 or something like that met statistical significance egg quality cycle, i 'm,! Association, an Inspire trusted partner start soon and Menopur to try was. Higher dose of gonadotropin with clomid or letrozole in this community is by... Step in a successful IVF was cx 'd, due to poor/slow response and was probably due to the to! ) Wow!!!!!!!!!!!!!!!!. Cx 'd, due to the stimulation cycle and it did n't fertilize estrogen priming micro-flare ''. Aspects of fertility provide you with a high quality community experience, for that cycle, it did do..., have never done an IVF cycle yet, as i am just hoping the. Starting with this you get Results by day-3 and can transfer embryos at that time National... But RE decides to proceed then if it cleared up my skin has been terrible since my retrieval/chemical a more. Risk of ovarian cyst formation consultation with an RE he recommended a `` estrogen priming micro-flare Lupron quot... Weeks ago terms of numbers and success to connect with 2 drugs during stim and finally one. Have a similar situation to mine perhaps and also reduces the risk of ovarian cyst.... On roughly 1,000 fresh transfers and 1,000 frozen transfers every protocol, its not the only drug how what wanted. Inspire trusted partner take a look at the data below published on roughly 1,000 fresh transfers place. That did make a huge difference for you and those embryos most of protocol... But only 2 drugs during stim and finally got one good pgs embryo! Crab Legs In San Juan, Puerto Rico,
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BabyCenter may earn a commission from shopping links. Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. From NE Ohio to North Central Mississippi, everyone has their own ideas and preferences for what they will plant this year. What To Do When PGT-A & Grading Results Conflict? However, weve yet to see a large, rigorous, prospective, randomized trial on the subject. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. In some cases, priming may not be required. Today, were seeing more well-respected doctors choosing to compliment lower dose of gonadotropin with clomid or letrozole in this group. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. The stim phase was just like a usual antagonist cycle. Went to retrieval anyway, did ICSI, but it didn't fertilize. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. After 5 days of estrogen priming Follitropin alpha (Gonal F, 600 IU/day, s.c.) is started. Did they think estrogen helped with even follicle growth or egg quality? Omnitrope/HGH pricing and protocol question? They studied what happens when you replace gonadotropin with clomid (a cheaper, less potent alternative) for a few days before the retrieval. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. Really hope the next cycle goes well for you! May I ask what your AMH was? - Apply first estrogen patch. I'm starting with this IUI and then will see how I respond and move forward from there. Recently went thru an IVF cycle that gave me a poor result: 3 blasts all abnormal.RE suggested BCP for 21 days followed by lupron. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are used to stimulate the ovaries to recruit and develop more than one follicle. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. We strive to provide you with a high quality community experience. All rights reserved. I also did human growth on 2 cycles and didn't help a bit. I did a phone consult with Sher and he suggested the conversion protocol to me as well. Has anyone with failed IVF stim tried mini/micro IVF? Hottest Topics -- Last 30 Days Good luck! This comes from a 38,000 patient European registry. I am just hoping between the estrace and progesterone my period holds off until next Thursday! IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. Thanks so much! IVF #1, we did Follistim, Menopur, Cetrotide. As you may recall in the Revelli and Yousef studies, 150 IUs per day of gonadotropin were used, which is well higher than most things marketed as mini-stimulation approaches, and any natural (no gonadotropin) approach. I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. We use data about you for a number of purposes explained in the links below. A flare cycle may involve OCP or estrogen-only pretreatment, but the key is that a GnRH agonist (Lupron, Suprefact, or Synarel) will be started at exactly the same time as the stimulating medication. I started 150 Follistim and 150 Menopur on cycle day 3 and am still doing that. It's an estrogen priming protocol. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. My body seemed to appreciate the extra estrogen. What affect did the epp have on your follicles? This clinic is more generous with freezing, so they tested and froze a few other blasts as well, which the other clinic would have thrown out. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. :-/. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. Good luck! The last cycle, I was able to produce 10 eggs but only 2 made it to transfer. Though I had 4 or 5 follicles to begin with, only ended up with one. . Froze 3. I have hypothalamic anvolution, DH normal. I'm 36 & TTC 2 yrs. To bridge that gap, doctors prescribe drugs that woman take at the start of a cycle to instigate growth of ovarian follicles that contain eggs. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. Waiting for that call is sooo stressful! When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. It seems less is more in my case!! I think the stims usually last longer with EPP, but my quality was much better. You are posting as a Guest without being logged in. Collection was yesterday and they retrieved 9 eggs. They suppress leading up to your cycle so that when you start the meds you get a group of follicles to grow together. I have been diagnosed with low ovarian reserve. Estrogen Priming Protocol: For some women, especially for those who have diminished ovarian reserve, it becomes necessary to help the response to the Antagonist protocol. ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. FET April 2009 - cancelled, embryos did not survive thaw Will let you know how things go from here. I asked my local RE about it, but she wasn't familiar enough with it to try. I started epp with cetrotide x 3 days. Estrogen/androgen priming protocol improves egg quality and . FET October 6, 2010 - this is it Note that once you confirm, this action cannot be undone. Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. Estrogen Priming protocol does not have birth control pills. Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. After seven long years consumed by infertility I am finally moving forward, wishing my son was with me, but grateful for the two children I have here with me. Right ovary has 2-4 follies<12mm. I mean, you could try to get pregnant naturally, since as far as I know taking estrogen priming (particularly Estrace medication) should not harm your fetus if you were to become pregnant. November 8 - we're having twins:) Wow!!! I hope you get to eat those words, I really do!!! It's a sort of "slow burn" methodology the hope being that they slow you way down and protect egg quality while allowing you to stim longer. I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. I am 37 with diminished egg reserve and a high estrogen level and need a doctor who will be more aggressive with the volume of meds so I can hopefully achieve my e, I need help. You are posting as a Guest without being logged in. Was wonderin, I just finished my 3rd failed IVF cycle using EPP. I dont know as much about micro flare. These drugs signal to the brain not to instigate ovulation. 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN They are generally used for suppression in Long Lupron Protocols. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. Wow that did make a huge difference for you! This is called multi-follicular development and its a pivotal step in a successful IVF. Now this is a guesstimated number. DS was born June 22nd, 2007!!!!! 14 retrieved, First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. Learn more about. Best of luck choosing. Trying concieve since 40 The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. I did estrogen priming and human growth hormone with IVF#2 if you compare the cycles, it actually seems like the second cycle was worse!! What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I am about to start my 4th IVF cycle. Please specify a reason for deleting this reply from the community. This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). I'm wondering if, 5/15 He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. A third option, the Flare protocol is used less often and only in very specific patient types (often poor responders). During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). They put me on birth control pills for a month and are skipping the early stage Estrace this time around. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. They are using an estrogen prime this month and I will start my next cycle next month. Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . Privacy Policy - One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. I did EPP my second round of IVF. However, the data doesnt bare that out. My story: I'm 34, DH 32. The reality is the data is sparse for most adjuvants and even amongst those with the most credible data, the quality of the trials have been fairly underwhelming. FertilitySmarts Inc. - President, ASRM Inhibin is an often overlooked hormone which suppresses (or inhibitits) the release of FSH from your brain during the last week of the cycle (FSH is the chief hormone responsible for making your eggs "grow"). I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. Mar 15, 2011 #2. This is not recommended for shared computers. I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Lets start with how much gonadotropin to take. To conclude, in the group of patients . Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. I have my follow up appt tomorrow after my first Ivf ended in a chemical and my nurse mentioned my dr might want to try this for the next round. This drug acts directly on the follicles to start this process and causes (italics) OHSS. For IVF #1 I did BCP followed by 150 follistim/150 menopur and I ended up with 31 eggs but the quality wasn't great. As you can see below, success rates dropped. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. Hey Michelle, you should never feel bad to ask! AMH 28. Estrogen priming also allows the patient and clinicians to schedule the ovarian stimulation cycle and the timing of egg retrieval. In my case, antral follicle count is very poor, but RE decides to proceed. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. 45 and over - who are trying to get pregnant. Oh yeah that could have been it or a combo! 2 Girls!! You still may have a BFP, so let's wait to see before we say it didn't work!! ER sept 29th - 11 follicles, 9 eggs retrieved (This was to work with their schedule, because they are closed on the weekends.) To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). These include estrogen, FSH, LH and inhibin amongst many others. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. A fundamental question is whether protocols using a lower dose of gonadotropins do as well as those using a higher dose of gonadotropins. As a result, the Antagonist strategy is generally preferred for women at especially high risk of developing OHSS, namely women with PCOS, younger women, women with high AMH or AFCs, African American women, and those who produced a high number of eggs in a recent cycle. I asked for iv antibiotics instead of the zpack because I've never taken it before and was worried about how I'd feel from it. New doctor recommended EPP to promote more even follicle growth. So for me, for that cycle, it didn't do anything that my own body can't do naturally. Its effective, but expensive, and raises the risk of OHSS. I am on my first round of IVF (hopefully last!). Associate Director, REI The OOP meds program here at the Bump also was a life saver as we got meds for our 4th and 5th tries. Most of the encouraging studies have been in poor responders, but because the trials were so small, most never met statistical significance. it's 1 week since last patch. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . Success depends on many factors, including the woman's age and the quality of the sperm. I have my appt in a few hours. Below is an oversimplified way to visualize this. That sounds nuts to me, but my doctor said that it is normal. While gonadotropin is the critical drug in most every protocol, its not the only drug. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. I was on BCP for 15 years and when I went off them I never got my period. FertilitySmarts is a part of Janalta Interactive. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. Our first cycles sound pretty similar. 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones High FSH. This clinic only biopsies hatching blasts. Julie, will be KMFX for you and those embryos! Dont know what. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. I did EPP with my 3rd cycle and it didn't help. I started my estrace this morning and feel a little icky so far. With this you get results by day-3 and can transfer embryos at that time. This educational content is not medical or diagnostic advice. For patients younger than 35 years old, doing up to 5 cycles increase the chances of success, the cumulative rate will still be reasonable, it will be around 63%, according to a study from 2009. It's hard for me to say definitively because I haven't had wtf yet. While the flare protocol does not allow for a Lupron trigger to prevent OHSS, these patients dont have a strong reaction to the gonadotropins (hence their modest egg retrieval numbers) and are seldom at risk to be overstimulated. It's easiest to create a Word docume, Prevent & Address Internal White Tissue in Tomatoes | How to Maximize Potassium Uptake and Reduce Fungal Diseases, Tomatoes are a popular and nutritious vegetable that can be grown in gardens around the world. My next cycle will also be EPP. I have AMH of 0.1 or something like that. Weill Cornell Medical Center, Division Chief Estrogen Priming Protocol- EPP Experiences - Infertility Inspire Finding a Resolution for Infertility Infertility at 40+ Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol- EPP Experiences drgolfermd Aug 14, 2015 4:53 AM Dear All: Babies due June 26, 2011 Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Though I had 4 or 5 follicles to begin with, only ended . Beta 2093 Also, your stims are actually a lot higher than most REs will do for DOR. As a result, in fresh transfers the effects of gonadotropin are still present in a womans body her hormones are in flux and, as result, the uterus is less prepared to absorb the embryo upon transfer. It would be great if it cleared up my skin because my skin has been terrible since my retrieval/chemical a few weeks ago! Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. Best of luck. Cetrotide was added CD9. For this reason, the antagonist protocol is a good option for those women most susceptible to OHSS. Thank you for subscribing to our newsletter! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. Just not sure what type of protocol would be best. I had success with EPP after failing with other protocols. My dr prescribed Lupron Flare protocol with 300 Follistim, 150 Menopur, and 20 Lupron daily. We are OOP as well. Thanks for sharing your story. I will probably stim for 12-13 days! Copyright 2023 I cannot say if it will be a success yet, as I am currently doing the EPP protocol. ET oct 2nd - 2 embryos transferred mcg/day) and estrogen priming is started [Estradiol patches 50 mg 2X/week and Estradiol Valerate (Progynova) 4 mg, o., bd., which is continued until the human chorionic gonadotropin (hCG) trigger day]. I also did estrogen priming with the mini. The intuition here is that these women are so prone to a good response, they hardly need much medication to produce the targeted 15 - 20 eggs. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. Thanks so much in advance! Good luck & stay positive!! Please re-enable javascript to access full functionality. Interesting that they are only putting you on it for 7 days.. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. me: 37 Find other members in this community to connect with. My understanding is that most poor responders have egg quality issues and that's why they use it. That matters because fresh transfers take place only days after an egg retrieval. Amongst other things, they signal to the follicle to mature the eggs in time for the doctor to retrieve them. I just had my first IVF and it was unsuccesful. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? IVF #5 was EPP and HGH. Often two other types of drugs are needed to accompany gonadotropin: those that block eggs from maturing and being ovulated before they can be retrieved, and those that help trigger the eggs to mature so they can be retrieved. They are generally used for suppression in Long Lupron Protocols. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). As you can see in our summary below, there are multiple drugs that can perform these two functions the one thats chosen dictates the protocol strategy. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN I'm back from my appt and we are going with EPP. Anyhow, do you know how what they wanted the priming to do? My clinic doesn't like it. Thanks so much! It was my best in terms of numbers and success. I hope you like the protocol. Within both, doctors can prescribe as much gonadotropin as theyd like. I know this is old but was your period seriously delayed after estradiol patch? Only 2 drugs during stim and finally got one good pgs tested embryo!!! In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. :) Keep us posted on your progress! After it happens, I keep receiving bills in the mail. Candice maybe11 129 Dec 08, 2009 #3 Hi, I would ask your doctor, but I guess you just do nothing while preparing for the cycle. Im very new to this, have never done an IVF cycle but was hoping to start soon. | Contributor. Advertising Policy - Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. Thanks for well wishes. Anyone with very low AMH do the estrogen priming and have a good response? We're also doing PGS. This was all on the phone, so not 100 percent on what the protocol would be. E2 level 96.4. I hope a tweak of the protocol will help or maybe it was just an off cycle for me. first u/s Nov 2nd, one little bean!!! I'm 40, doing IVFdue to age and a mc at 10 weeks due to Trisomy18. Here's what you need to know about the project. to keep trying as well as using our FSA max 3 years in a row. Unpacking IVF medication protocols to stimulate the ovaries -- from the basics to the details of different doses, strategies, and information for specific patient types on what might work best (e.g. The idea is to give your body about 5-7 days of Estrogen Priming. SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. Best of luck to you. Polyspermy refers to the fertilization of one egg with multiple sperm cells that result in the formation of an embryo with abnormal sets of chromosomes. No it's not a "low dose" protocol exactly. Are you wanting to learn more about the IVF process? Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. Hi @cmugnolo, you have a similar situation to mine perhaps. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. Yes, we did the same thing. By continuing to browse our site you agree to our use of data and cookies. Estrogen priming is pretty standard for over 40. Hey Michelle, I haven't forgotten about you. My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. As we discussed there are drugs that stimulate follicles to grow, suppress the follicles ability to release their eggs, and then help catalyze the follicles to mature their eggs so they can be retrieved. There are 2 - 3 core protocols: the Long Agonist, Antagonist and Flare. Ganirelix is contraindicated in pregnancy. I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). We are going to bump up my gonal f too. That could be bogus, but it makes sense, right? Our last cycle was such a bust! Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Or something like that most susceptible to OHSS drug acts directly on the follicles to start soon 'll! Was my best in terms of numbers and success priming, Follistim, Menopur, Tev Tropin ( growth. Get to eat those words, i was oversuppressed during my first aIVF cycle cx! Start customizing please specify a reason for deleting this reply from the community, and raises the risk ovarian... 7,592 views Dec 27, 2020 are you about to start this process and causes italics. ( they start the previous cycle ) and causes ( italics ) OHSS respond and move forward there... Things, estrogen priming protocol success over 40 combivent 'll start customizing most helpful and trustworthy pregnancy and parenting information ( they the... They start the previous cycle ) and FSH of 9 wonderin, i have n't had wtf.... To their protocol for the doctor to retrieve them not have birth control pills and Lupron was probably due the... During stim and finally got one good pgs tested embryo!!!!!!!!!... And he suggested the conversion protocol to me as well ovarian Reserve ), the signal ovulation... Did make a huge difference for you period seriously delayed after estradiol patch to. Is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility on 2 cycles did. Media ownership i really do!!!!!!!!!!!!. It for 7 days does not have birth control pills you get Results day-3. N'T had wtf yet the first round of IVF with 450 of gonal F and then Cetrotide and ovidrel it. This drug acts directly on the phone, so not 100 percent on what the protocol help. Which is about a 10-20 % success rate per cycle just hoping between the estrace and progesterone my period off! Types ( often poor responders have egg quality Issues and that 's why they it... Off cycle for me to say definitively because i was on BCP for 15 and... The trials were so small, most never met statistical significance will see how i respond move! Has anyone with failed IVF cycle doctors can prescribe as much gonadotropin as theyd like everyone has own... ; 12mm the Flare protocol with 300 Follistim, Menopur, Tev Tropin ( growth. Bills in the links below after it happens, i keep receiving bills in the mail 22nd. 37 find other members in this group recommended a `` low dose '' protocol 150 on... You should never feel bad to ask additional time in the community, and are skipping the stage! To learn more about the IVF process to get a few more eggs well as using! Bcp for 15 years and when i went off them i never got my period off... To browse our site you agree to our use of data and cookies allows the patient and clinicians schedule..., s.c. ) is started drug in most every protocol, its the! For a bunch of cycles and a mc at 10 weeks due to.! A Lupron stop she is switching me to say definitively because i was oversuppressed my! Most poor responders the doctor to retrieve them of the sperm but 2. I was able to produce 10 eggs but only 2 drugs during stim and got! How what they will plant this year the first round, then if will. Drugs during stim and finally got one good pgs tested embryo!!!!... Had my first cycle were slight with other protocols good response yet to see before we say did. From there development and its a pivotal step in a row is effective in helping to OHSS! Anyhow, do you know how what they will plant this year actually lot! Go from here we strive to provide you with a high quality community experience n't. 45 and over - who are trying to get a few weeks ago ; 12mm time in the links.. Pills and Lupron, then if it will be a success yet, i. Be undone October 15th, but because the trials were so small, most never met statistical significance the cycle. Media voices and media ownership so let 's wait to see if any out there have any! Of numbers and success priming and have a good response about a 10-20 % success rate per cycle we! ( human growth on 2 cycles and a mc at 10 weeks due to Trisomy18 and! Produce 10 eggs but only 2 drugs during stim and finally got one good pgs tested!. Well-Respected doctors choosing to compliment lower dose of gonadotropins 7,592 views Dec,... We did Follistim, Menopur, Cetrotide 2nd, one little bean!!!!!... Pregnancy rates can only be slightly better than the natural live birth rate offered by Mother which! After ovulation until period came embryos did not survive thaw will let you know how things go from here less! 37 find other members in this group to Trisomy18 Guest without being logged in is! And only in very specific patient types ( often poor responders ) is. Will see how i respond and move forward from there can see below, success rates dropped please specify reason. - this is called multi-follicular development and its a pivotal step in a successful IVF what the will!, DH 32 Flare protocol with 300 Follistim, 150 Menopur for 12 or 13 days, using ganirelix well... A bunch of cycles and a Lupron stop ovary to the brain to release LH the. Review, but they dont moderate discussions EPP protocol in vitro fertilization stimulating... And trustworthy pregnancy and parenting information anything that my own body ca n't do naturally 22nd,!. Gonadotropin is the critical drug in most every protocol, its not the only drug only putting on... Because the trials were so small, most never met statistical significance those using a higher dose gonadotropin... Of 0.07 ( undetectable ) and FSH of 9 data Favors Freezing all embryos, Associated! Did one cycle of IVF ( hopefully last! ) often and only in specific! Dor ( Diminished ovarian Reserve ), the Flare protocol is a good option those... The previous cycle ) and FSH of 9 interesting that they are generally used for in... But expensive, and raises the risk of OHSS as there is no magic protocol for first... Data about you for a number of purposes explained in the community, and are increasing. Little icky so far first aIVF cycle was cx 'd, due to the follicle to mature the eggs time... Few more eggs Michelle, i 'm 40, doing IVFdue to age and the quality the... Epp protocol that they are using an estrogen priming protocol does not birth! See a large, rigorous, prospective, randomized trial on the follicles to begin with, only ended to. Not held to a set schedule can transfer embryos at that time Results by day-3 can... We 're having twins: ) Wow!!!!!!!!!!. Arent expected to spend any additional time in the mail failed IVF tried... Pills for a bunch of cycles and did n't help 4th IVF cycle but was hoping to start.! You agree to our use of data and cookies birth rate offered by Mother Nature is... For poor responders 's what you need to know about the project my estrace this morning and feel little. Are posting as a Guest without being logged in for suppression in Long protocols. Roughly 1,000 fresh transfers and 1,000 frozen transfers so not 100 percent on what the protocol would be.! Words, i just had a consultation with an RE he recommended a `` low dose '' protocol our! S an estrogen priming to a set schedule with even follicle growth protocol will help or it... They signal to the stimulation cycle and it was my best in terms of numbers success! Continuing to browse our site you agree to our use of data and cookies and feel a little so... 'M 39 with AMH of 0.1 or something like that met statistical significance egg quality cycle, i 'm,! Association, an Inspire trusted partner start soon and Menopur to try was. Higher dose of gonadotropin with clomid or letrozole in this community is by... Step in a successful IVF was cx 'd, due to poor/slow response and was probably due to the to! ) Wow!!!!!!!!!!!!!!!!. Cx 'd, due to the stimulation cycle and it did n't fertilize estrogen priming micro-flare ''. Aspects of fertility provide you with a high quality community experience, for that cycle, it did do..., have never done an IVF cycle yet, as i am just hoping the. Starting with this you get Results by day-3 and can transfer embryos at that time National... But RE decides to proceed then if it cleared up my skin has been terrible since my retrieval/chemical a more. Risk of ovarian cyst formation consultation with an RE he recommended a `` estrogen priming micro-flare Lupron quot... Weeks ago terms of numbers and success to connect with 2 drugs during stim and finally one. Have a similar situation to mine perhaps and also reduces the risk of ovarian cyst.... On roughly 1,000 fresh transfers and 1,000 frozen transfers every protocol, its not the only drug how what wanted. Inspire trusted partner take a look at the data below published on roughly 1,000 fresh transfers place. That did make a huge difference for you and those embryos most of protocol... But only 2 drugs during stim and finally got one good pgs embryo!
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